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Under the supervision of Drs. M. Cristina Kenney and Baruch Kuppermann, international and American clinical retinal physician scientists are trained in the most current translational research techniques.
These physician researchers will return to their home institutions to carry on the research. DEF also provides support to gain translational research experience in eye diseases for:
- Post-Doctoral Fellows
- Pre-Clinical Fellows
- Medical Students
- Undergraduates
- Foreign Research Fellows
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DR. KLASSEN'S PRESENTATION ON RETINAL STEM CELLS - MARCH 9, 2010
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DEF-funded prototype vaccine shows promise in preventing eye and other diseases.
A priority of The Discovery Eye Foundation (DEF) is the research of ocular herpes (OH) and infectious blindness. In addition to causing swelling, redness, watery eye discharge, sensitivity to light, or even blisters on the eyelids, OH - or herpes of the eye - can cause severe scarring of the cornea, the transparent dome-shaped membrane that covers the center eye.
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Ocular Herpes: Learning how to prevent ocular herpes and infectious blindness. - Researchers supported by DEF have made great progress in understanding the molecular mechanisms of ocular herpes including its latency, reactivation, and scarring. Scientists continue to gain an understanding of LAT, the major virus gene active during herpes latency, including its central role in keeping the virus invisible between attacks and ways in which it inhibits the body's immune response to the herpes infection.
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Retinal regeneration is a new and innovative approach to help replace damaged retinal cells using stem cells and other modalities to prevent vision loss and facilitate the restoration of lost vision. Age-related macular degeneration is reaching epidemic proportions as the US and world population ages—it is estimated that over 30% of people over the age of 70 in the US show some symptoms of this condition.
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Corneal Transplantation, Corneal Scarring and Its Prevention. Corneal transplantation is undergoing a revolution with new technologies that are being investigated to improve results, including lasers and the use of corneal stem cells. Scientists are studying the causes of corneal scarring after trauma, surgery and disease to understand the molecular causes and to harness new therapies to prevent corneal blindness. Regenerative Medicine and Biology is a new discipline being applied to the eye including the cornea as means to replace a cornea without the need for human donor corneas.
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DEF supported research into the medical and surgical treatments for glaucoma is a very important strength in the Department of Ophthalmology at University of California, Irvine.
Dr. George Baerveldt has developed an FDA approved new surgical instrument and technique for treatment of glaucoma. DEF supported scientists are helping to understand why surgical treatment for glaucoma sometimes fails and are in the process of designing treatments to improve surgical results.
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Ongoing research conducted by scientists at the Morris S. Pynoos Eye Research Laboratories at the University of California, Irvine, and the UCI Center for Molecular and Mitochondrial Medicine and Genetics, is leading to a better understanding of the ways to prevent programmed cell death or "apoptosis,” which is the cause of many ocular diseases. The new field of mitochondrial research is aimed in great part at understanding how to prevent this cell death that is found in the aging and many diseases.
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